Uracil mustard revisited
نویسندگان
چکیده
منابع مشابه
Uracil mustard in the treatment of thrombocythemia.
T HROMBOCYTHEN’IIA with platelet counts of over 1,000,000 per cu. mm. may occur in a number of myeloproliferative disorders and may be associated with both thrombosis and hemorrhage. Either busulphan or radioactive phosphorus is generally used to reduce high platelet counts when they occur in these disorders. However, neither of these means of treatment is entirely satisfactory. A prolonged cou...
متن کاملEffects of uracil mustard on DNA, RNA, and protein biosynthesis in tissues of A-J mice.
The effects of 5-bis(2-chloroethyl)aminouracil (uracil mustard) on some of the biochemical events occurring in lung were studied since this compound, a reactive alkylating agent and analog of uracil, markedly increased the incidence and number of lung tumors in strain A/J mice. Similar measurements were per formed in kidney and liver, organs which do not undergo a tumorigenic res]x>nse to uraci...
متن کاملCrystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
The DNA repair enzyme uracil DNA glycosylase (UDG) catalyzes the hydrolysis of premutagenic uracil residues from single-stranded or duplex DNA, producing free uracil and abasic DNA. Here we report the high-resolution crystal structures of free UDG from Escherichia coli strain B (1.60 A), its complex with uracil (1.50 A), and a second active-site complex with glycerol (1.43 A). These represent t...
متن کاملQUICKSELECT Revisited
We give an overview of the running time analysis of the random divide-and-conquer algorithm FIND or QUICKSELECT. The results concern moments, distribution of FIND’s running time, the limiting distribution, a stochastic bound and the key: a stochastic fixed point equation.
متن کاملUracil photoproducts from uracil irradiated in ice.
Two new products were isolated from uracil irradiated with ultraviolet light in frozen aqueous solution. As judged by mass, nuclear magnetic resonance, and ultraviolet and infrared spectra, one is a photopolymer, U(3) and the structure of the other is probably 6-4'-[ pyrimidin-2'-one]-uracil. Formations of these products between pyrimidine bases are apparently common photoreactions, and may be ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 1999
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(19990515)85:10<2265::aid-cncr23>3.3.co;2-0